Hepato-Protective Effect of Telfaria occidentalis (Ugwu) Leaves Supplementation in Paracetamol Induced-Toxicity in Rats

The hepato-protective effect of Telfaria occidentalis leaves supplementation on paracetamol induced liver toxicity in wistar rats was investigated. A total forty Wistar (female and male) weighing between 150-250g were selected for the study. animals randomly divided into four groups five each. Animals group 1 2 received standard chow only while 3 4 5% 10% T. their feed respectively six weeks. Group 2, administered 3000 mg/kg bodyweight intraperitoneally after sacrificed 24hours induction harvested analysis. Alanine transaminase, Aspartate Transaminase Alkaline Phosphatase, protein, bilirubin direct measured homogenate following methods. significant decrease level ALT, AST ALP, Bilirubin increased protein observed when compared with 2. This study showed that possess protective potential supplemented diet thereby preventing deleterious effects might arose from overdose or overuse. concluded is percentage (dose) dependent.